Cell Surface Glycoprotein MUC18 Blocking Peptide

General Information

Product

Cell Surface Glycoprotein MUC18 Peptide

Description

Antigenic Blocking Peptide Cell Surface Glycoprotein MUC18 Antibody

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 330-353 on rat Cell Surface Glycoprotein MUC18 protein.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q9EPF2

Overview

lays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Detected in lung, uterus and placenta (at protein level). Detected in heart, lung, kidney, adrenal gland, intestine, testis, skeletal muscle and aorta. Detected at low levels in adult brain, in particular in brain stem and spinal cord, but also in hippocampus, olfactory bulb and striatum (at protein level).

Structure

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Alternative Nomenclature

A32 antigen antibody

CD 146 antibody

Cell surface glycoprotein MUC18 antibody

Cell surface glycoprotein P1H12 antibody

Gicerin antibody

Mcam antibody

Melanoma adhesion molecule antibody

Melanoma associated antigen A32 antibody

Melanoma associated antigen MUC18 antibody

Melanoma associated glycoprotein MUC18 antibody

MelCAM antibody

MUC 18 antibody

S endo 1 antibody

S endo 1 endothelial associated antigen antibody