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General Information
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Product
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Myocilin Peptide
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic Peptide
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Accession #
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GenBank: BAA24532.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:200
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Immunocytochemistry
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1:200
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Immunofluorescence
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1:200
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Immunohistochemistry
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1:200
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Competition/Depletion assay
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1:500
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Protein
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Uniprot #
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Q99972
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Overview
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Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction.
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Molecular Function
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fibronectin binding, myosin light chain binding, frizzled binding
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Subcellular Location
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Secreted, Golgi apparatus, Cytoplasmic vessicle
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Expression
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Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
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Structure
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Homodimer (via N-terminus). Interacts with OLFM3, FN1, NRCAM, GLDN and NFASC. Interacts (via N-terminus) with MYL2. Interacts with SFRP1, FRZB, FZD7, FZD10, FZD1 and WIF1; regulates Wnt signaling. Interacts with SNTA1; regulates muscle hypertrophy. Interacts with ERBB2 and ERBb3; activates ERBB2-ERBB3 signaling pathway. Interacts with SNCG; affects its secretion and aggregation.
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Alternative Nomenclature
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Glaucoma 1 open angle antibody
GLC1A antibody
GPOA antibody
JOAG antibody
JOAG1 antibody
Mutated trabecular meshwork-induced glucocorticoid response protein antibody
MYOC antibody
Myocilin antibody
TIGR antibody
Trabecular meshwork-induced glucocorticoid response protein antibody
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Myocilin Antibody
Myocilin Antibody FITC
Myocilin Antibody BIOTIN
Myocilin Positive Control
