Nicotinic Acetylcholine Receptor alpha 7 Blocking Peptide

General Information

Product

Nicotinic Acetylcholine Receptor alpha 7 Peptide

Description

Antigenic Blocking Peptide Neuronal acetylcholine receptor subunit alpha-7

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

Synthetic peptide corresponding to exon 5 of alpha 7-2 nAChRs protein.

Accession #

GenBank: XP_008757720

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

1:250

Protein

Uniprot #

Q05941

Overview

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Molecular Function

Ion channel, Ligand-gated ion channel, Receptor

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Structure

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.

Alternative Nomenclature

7nAChR antibody

A7 nicotinic acetylcholine receptor antibody

alpha-7 subunit antibody

AChR antibody

Acra7 antibody

Alpha 7 neuronal nicotinic acetylcholine receptor antibody

Alpha7 antibody

Alpha7 nicotinic receptor antibody

Cholinergic receptor nicotinic alpha 7 antibody

CHRNA7 antibody

CHRNA7-2 antibody

NACHRA 7 antibody

Neuronal acetylcholine receptor protein alpha 7 chain precursor antibody

Nicotinic acetylcholine alpha 7 subunit antibody

Schizophrenia neurophysiologic defect candidate antibody