PDE4 Blocking Peptide

Product no.: P-PD4

$155.00

Description
Publications

General Information
Product	PDE4 Peptide
Description	Antigenic Blocking Peptide Phosphodiesterase 4
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Overview	Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development.
Molecular Function	3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP catabolic process; signal transduction; Hydrolase
Subcellular Location	Cell membrane; Multipass membrane protein
Expression	Low expression during growth and cell aggregation (up to 6 hours), maximally increases after 9 hours of starvation, during the mound stage. Remains expressed at significant levels during the other stages of multicellular development.
Structure	Belongs to the cyclic nucleotide phosphodiesterase family.
Alternative Nomenclature	PDE4A antibody PDE4B antibody PDE4C antibody PDE4D antibody Phosphodiesterase 4 antibody Phosphodiesterase 4A antibody Phosphodiesterase 4B antibody Phosphodiesterase 4C antibody Phosphodiesterase 4D antibody

Protein information supplied by UniProt

Fabgennix PDE4 Antibody has been used in 14 Publication
Castiglione, Fabio, et al. "Inhibition Of Phosphodiesterase 4 Enhances Clitoral And Vaginal Blood Flow Responses To Dorsal Clitoral Nerve Stimulation Or PGE1 In Anesthetized Female Rats."Journal Of Sexual Medicine 10.4 (2013): 939-950. PMID23347325	Confocal Microscopy, Immunofluorescence; Rat
Wang, Zhen‐Zhen, et al. "RNA interference‐mediated phosphodiesterase 4D splice variants knock‐down in the prefrontal cortex produces antidepressant‐like and cognition‐enhancing effects." British journal of pharmacology 168.4 (2013): 1001-1014.PMID23003922	Western Blot; Mouse
Liu, Shubai et al. “Phosphodiesterases Coordinate cAMP Propagation Induced by Two Stimulatory G Protein-Coupled Receptors in Hearts.”Proceedings of the National Academy of Sciences of the United States of America 109.17 (2012): 6578–6583. PMC3340097	Western Blot; Mouse
Bogard, Amy S., Piyatilake Adris, and Rennolds S. Ostrom. “Adenylyl Cyclase 2 Selectively Couples to E Prostanoid Type 2 Receptors, Whereas Adenylyl Cyclase 3 Is Not Receptor-Regulated in Airway Smooth Muscle.”The Journal of Pharmacology and Experimental Therapeutics 342.2 (2012): 586–595. PMC3400804	Western Blot; Human, Mouse
Muzaffar, Saima, et al. "NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in Human endothelial cells." Journal of cellular physiology 227.5 (2012): 1941-1950.PMID21732365	Western Blot; Human
Li, Yun-Feng, et al. "Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling." The Journal of Neuroscience 31.1 (2011): 172-183.PMID21209202	Immunohistochemistry, Western Blot; Human
Wang, Wayne C. H. et al. “Paradoxical Attenuation of Β2-AR Function in Airway Smooth Muscle by Gi-Mediated Counterregulation in Transgenic Mice Overexpressing Type 5 Adenylyl Cyclase.” American Journal of Physiology - Lung Cellular and Molecular Physiology 300.3 (2011): L472–L478. PMC3064290	Western Blot; Mouse
Yagi, Kenji, et al. "Ibudilast Inhibits Cerebral Aneurysms by Down‐Regulating Inflammation‐Related Molecules in the Vascular Wall of Rats." Neurosurgery 66.3 (2010): 551-559.PMID20124930	Immunohistochemstiry; Rat
Dodd-o, Jeffrey M., et al. "The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact Mouse." American Journal of Physiology-Lung Cellular and Molecular Physiology 294.4 (2008): L714-L723. PMID18223163	Western Blot; Mouse
Ückert, Stefan, et al. "Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora." The Journal of Sexual Medicine 4.3 (2007): 602-608. PMID17498099	Immunofluorescence; Human
Ückert, Stefan, et al. "Immunohistochemical distribution of cAMP-and cGMP-phosphodiesterase (PDE) isoenzymes in the Human prostate." European urology 49.4 (2006): 740-745. PMID16460876	Immunofluorescence, Immunohistochemistry; Human
Oelke, Matthias, et al. "Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the Human clitoris: immunohistochemical and molecular biology study." Urology 67.5 (2006): 1111-1116. PMID16635522	Confocal Microscopy.. Immunofluorescence; Human
Ückert, Stefan, et al. "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in Human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." Urology 65.3 (2005): 604-610. PMID15780401	Immunohistochemistry; Human
Ückert, S., et al. "Immunohistochemical presence of cyclic AMP-and cyclic GMP-phosphodiesterase isoenzymes in human clitoris." European Urology Supplements 2.1 (2003): 118.	Confocal Microscopy, Immunofluorescence; Human