PDE4A5 Blocking Peptide

General Information

Product

PDE4A5 Peptide

Description

Antigenic Blocking Peptide cAMP specific phosphodiesterase 4A variant pde46 

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic cyclic peptide specific only for PDE4A5 protein. N-terminal sequence modified to achieve desired antigenicity and linker for covalent coupling to blue carrier protein.

Accession #

GenBank: EAW74861.1 

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P27815

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Molecular Function

Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding

Subcellular Location

Isoform 1: Cytoplasm › perinuclear region, Isoform 2: Cytoplasm, Cell projection, Isoform 4: Membrane; Peripheral membrane protein Isoform 6 : Cytoplasm › perinuclear region Isoform 7 : Cytoplasm. Membrane

Expression

Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in teh heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and periphereal blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).

Structure

Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2.

Alternative Nomenclature

5''-cyclic phosphodiesterase 4A antibody

cAMP specific 3 5 cyclic phosphodiesterase 4A antibody

cAMP-specific 3'' antibody

DPDE2 antibody

dunce antibody

PDE46 antibody

PDE4A antibody

Phosphodiesterase 4 antibody

phosphodiesterase 4A cAMP specific antibody

phosphodiesterase E2 dunce homolog antibody