PGCB Blocking Peptide

Product no.: P-PGCB

$155.00

Description
Publications

General Information
Product	Natriuretic Peptide Receptor B / PGCB Peptide
Description	Antigenic Blocking Peptide Atrial natriuretic peptide receptor 2
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein.
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	P20594
Overview	Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Molecular Function	ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity
Subcellular Location	Membrane; Single-pass type I membrane protein
Structure	Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.
Alternative Nomenclature	AMDM antibody ANPB antibody ANPRB antibody peptide receptor type B antibody Atrionatriuretic peptide receptor B antibody GC-B antibody GUCY2B antibody Natriuretic peptide receptor B/guanylate cyclase B antibody NPR-B antibody NPR2 antibody NPRBi antibody

Protein information supplied by UniProt

Fabgennix PGCB Antibody has been used in 8 Publications

Muller, Dieter, et al. "Expression of guanylyl cyclase (GC)-A and GC-B during brain development: evidence for a role of GC-B in perinatal neurogenesis." Endocrinology 150.12 (2009): 5520-5529. PMID19837875

Immunocytochemistry, Immunohistochemistry, Confocal Microscopy; Rat

Thompson, Iain R. et al. “Homologous and Heterologous Desensitization of Guanylyl Cyclase-B Signaling in GH3 Somatolactotropes.” Cell and Tissue Research 355.2 (2014): 425–436. PMC3921447

Confocal Microscopy, Immunofluorescence, Western Blot; Human, Rat

Thong, Arief, et al. "Neutral endopeptidase (CD10) is abundantly expressed in the epididymis and localized to a distinct population of epithelial cells–Its relevance for CNP degradation." Molecular and cellular endocrinology 382.1 (2014): 234-243. PMID24099862

Immunofluorescence, Western Blot; Human, Mouse

D. Muller, et. al. "Cylic GMP signaling in rat urinary bladder, prostate, and epidiymis: tissue-specific changes with aging and in response to Leydig cell depletion." Journal Society for Reproduction Fertility. 2011 April; 10.1530 PMID21511885

Western Blot; Rat

Müller, Dieter, et al. "The Membrane Receptors Guanylyl Cyclase-A And -B Undergo Distinctive Changes In Post-Translational Modification During Brain Development D. Müller Et Al. Guanylyl Cyclase-A And -B Glycosylation In Brain." Journal Of Neurochemistry 115.4 (2010): 1024-1034.

PMID20880010

Western Blot; Mouse, Rat

Liu, Cambrian Y., Scott E. Fraser, and David S. Koos. "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." Journal of CompaRative Neurology 516.1 (2009): 36-48. PMID19565523

Immunofluorescence, Western Blot; Mouse

Thompson, Iain R., et al. "Molecular characterisation and functional interrogation of a local natriuretic peptide system in rodent pituitaries, αT3-1 and LβT2 gonadotroph cells." Journal of Endocrinology 203.2 (2009): 215-229 PMID19666697

Western Blot; Mouse

Zhu, Bing, Samuel Strada, and Troy Stevens. "Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 289.2 (2005): L196-L206. PMID15792963

Immunoprecipitation, Western Blot; Rat

Publishing research using PGCB-201AP? Please let us know, we can cite the reference in this datasheet.