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General Information
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Product
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Phospho-ErbB 2 Peptide
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Description
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Antigenic Blocking Peptide Receptor tyrosine-protein kinase erB-2 (HER2)
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Phoshporylated synthetic peptide taken within amino acid region 1100-1150 on human HER-2 protein
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Accession #
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GenBank: AAA75493.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P04626
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Overview
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Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).
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Molecular Function
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Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.
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Expression
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Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
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Structure
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Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG).
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Alternative Nomenclature
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Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody
c erb B2/neu protein antibody
CD340 antibody
CerbB2 antibody
Erb B2 antibody
Erythroblastosis Virus antibody
HER 2/neu antibody
Herstatin antibody
Metastatic lymph node gene 19 protein antibody
MLN19 antibody
NEU antibody
Neuro Glioblastoma Derived Oncogene Homolog antibody
NGL antibody
p185 ErbB2 antibody
Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody
TKR1 antibody
Tyrosine kinase-type cell surface receptor HER2 antibody
v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody
verbb2 antibody
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Phospho-ErbB 2 Antibody
Phospho-ErbB 2 Antibody FITC
Phospho-ErbB 2 Antibody BIOTIN
Phospho-ErbB 2 Positive Control
