Syncytin 2 Blocking Peptide

General Information

Product

Syncytin 2 Peptide

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 80-130 on human Syncytin-2 protein.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P60508

Overview

This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process (PubMed:18988732).1 Publication

Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (PubMed:14694139).

Molecular Function

Syncytium formation

Subcellular Location

Virion, Cell membrane

Expression

Expressed at higher level in placenta. Expressed at lower level in adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea.

Structure

Contains the CKS-17 immunosuppressive domain present in many retroviral envelope proteins. As a synthetic peptide, it inhibits immune function in vitro and in vivo.

Alternative Nomenclature

Endogenous retrovirus group FRD member 1 antibody
Envelope polyprotein antibody
ERVFRD-1 antibody
HERV FRD 6p24.1 provirus ancestral Env polyprotein antibody
HERV FRD antibody
HERV FRD provirus ancestral Env polyprotein antibody
SU antibody
Syncytin 2 antibody
Syncytin B antibody
TM antibody
Transmembrane protein antibody
UNQ6191 antibody