|
General Information
|
|
|
Product
|
Topoisomerase II alpha Peptide
|
|
Description
|
Antigenic Blocking Peptide DNA topoisomerase (ATP-hydrolysing) Antibody
|
|
Verified Applications
|
Immunocompeition, Immunodepletion
|
|
Peptide Description
|
Synthetic peptide taken within amino acid region 1220-1270 on human DNA topoisomerase (ATP-hydrolysing) protein.
|
|
Accession #
|
GenBank: CAA09762.1
|
|
Physical Properties
|
|
|
Quantity
|
250 µg
|
|
Volume
|
100 µl
|
|
Form
|
Antigenic Blocking Peptide
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
|
Protein
|
|
Uniprot #
|
P11388
|
|
Overview
|
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
|
|
Molecular Function
|
Isomerase, Topoisomerase, ATP binding
|
|
Subcellular Location
|
Cytoplasm, Nucleus
|
|
Structure
|
Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. Interacts with SETMAR; stimulates the topoisomerase activity.
|
|
Alternative Nomenclature
|
alpha isozyme antibody
ATP hydrolyzing DNA topoisomerase II alfa antibody
DNA gyrase antibody
DNA topoisomerase 2 alpha antibody
DNA topoisomerase II 170 kD antibody
DNA topoisomerase II alpha isozyme antibody
TOP2 antibody
TOP2A antibody
Topoisomerase DNA II alpha 170kDa antibody
TP2A antibody
|
| |
|
Topoisomerase II alpha Antibody
Topoisomerase II alpha Antibody FITC
Topoisomerase II alpha Antibody BIOTIN
Topoisomerase II alpha Positive Control
