|
General Information
|
|
|
Product
|
CX3CL1 Positive Control
|
|
Description
|
Western Blot Positive Control Fractalkine
|
|
Verified Applications
|
WB
|
|
Immunogen
|
Purified protein
|
|
Physical Properties
|
|
|
Quantity
|
5 Applications
|
|
Volume
|
Inquire
|
|
Form
|
Western Blot Positive Control
|
|
Purification Method
|
Immobilized antigen affinity chromatography
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
Western Blot
|
1:500
|
|
Protein
|
|
Uniprot #
|
O35188
|
|
Overview
|
Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9177350, PubMed:10382755).
|
|
Molecular Function
|
CCR chemokine receptor binding, chemokine activity, CX3C chemokine receptor binding, integrin binding
|
|
Subcellular Location
|
Cell membrane, Single-pass type I membrane protein, Processed fractalkine : Secreted
|
|
Expression
|
Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis.
|
|
Structure
|
Signal, Transmembrane, Transmembrane helix
|
|
Alternative Nomenclature
|
A 152E5.2 antibody
AB030188 antibody
ABCD3 antibody
AI848747 antibody
C-X3-C motif chemokine 1 antibody
C3Xkine antibody
Chemokine C X3 C motif ligand 1 antibody
CX3C membrane anchored chemokine antibody
Cx3cl1 antibody
CXC3 antibody
CXC3C antibody
D8Bwg0439e antibody
FKN antibody
Fractalkine antibody
Neurotactin antibody
NTN antibody
NTT antibody
Processed fractalkine antibody
SCYD 1 antibody
Small inducible cytokine D1 antibody
X3CL1_HUMAN antibody
|
| |
|
CX3CL1 Antibody
CX3CL1 Antibody BIOTIN
CX3CL1 Antibody FITC
CX3CL1 Blocking Peptide
