IFITM3 Positive Control

General Information

Product

IFITM3 Positive Control

Description

Western Blot Positive Control Interferon-induced transmembrane protein 3

Verified Applications

WB

Immunogen

Purified protein

Accession #

GenBank: AFF60350

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Purification Method

Immobilized antigen affinity chromatography

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q01628

Overview

IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Molecular Function

Antiviral defense, Immunity, Innate immunity

Subcellular Location

Cell membrane; Single-pass type II membrane protein

Late endosome membrane; Single-pass type II membrane protein

Lysosome membrane; Single-pass type II membrane protein

Expression

Induced by IFN-alpha and IFNG/IFN-gamma.

Structure

Interacts with ATP6V0B and CD81. Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.

Alternative Nomenclature

1 8U antibody

Fragilis antibody

IFITM3 antibody

Interferon Induced Transmembrane Protein 3 antibody

Interferon inducible antibody

Interferon inducible protein 1 8U antibody

Interferon Inducible Protein 15 antibody

Interferon Inducible Protein Homolog antibody

IP15 antibody