PDE9A Antibody

General Information

Product

PDE9A Antibody

Description

Affinity Purified High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic cyclic peptide common to all PDE9A variants.

Accession #

NCBI:  NP_002597.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:100

ELISA

1:100

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

O76083

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.

Molecular Function

Hydrolase, 3', 5' -cyclic-GMP phosphodiesterase activity

Subcellular Location

Isoform PDE9A1: Cell projection, Cytoplasm, Golgi Apparatus, Endoplasmic reticulum, Isoform PDE9A2: Cell projection, Cytoplasm, Isoform PDE9A3: Cytoplasm, Endoplasmic Reticulum, Isoform PDE9A17: Cytoplasm, Endoplasmic reticulum

Expression

Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.

Alternative Nomenclature

FLJ90181 antibody

HSPDE9A2 antibody

PDE 9A antibody

Pde9a antibody

Phosphodiesterase 9A antibody

phosphodiesterase PDE9A21 antibody