Adenylate Cyclase 10 Antibody

General Information

Product

Soluble Adenylate Cyclase 10 Antibody

Description

Affinity Purified Bicarbonate activated soluble adenylate cyclase 10 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Gorilla, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse Adenylate Cyclase type 10 protein.

Accession #

NCBI:  NP_766617.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q8C0T9

Overview

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.

Molecular Function

Adenylate cyclase activity; ATP binding; Magnesium ion binding; Manganese ion binding

Subcellular Location

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Expression

Expressed in testis.

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Alternative Nomenclature

3',5'-cyclic AMP synthetase antibody

Adenylate cyclase 10 (soluble) antibody

AH related protein antibody

ATP pyrophosphate-lyase antibody

Germ cell soluble adenylyl cyclase antibody

HCA2 antibody

hsAC antibody

hypercalciuria absorptive antibody

SAC antibody

SACI antibody

Sacy antibody

Soluble adenylyl cyclase antibody

Testicular soluble adenylyl cyclase antibody