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General Information
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Product
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TMEM16A Antibody
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Description
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Affinity Purified Transmembrane protein 16A Antibody N-epitope
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region on 70-120 on mouse Transmembrane Protein 16A.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.50 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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N-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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1:100 |
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q8BHY3
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Overview
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Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
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Molecular Function
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Chloride channel, Developmental protein, Ion channel
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Subcellular Location
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Cell membrane; Multi-pass membrane protein, Cytoplasm
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Expression
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Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.
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Structure
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Homodimer. Interacts with CFTR.
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Alternative Nomenclature
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ANO 1 antibody
Anoctamin 1 antibody
Anoctamin 1 calcium activated chloride channel antibody
Ca2+ activated Cl- channel antibody
Discovered on gastrointestinal stromal tumors protein 1 antibody
DOG 1 antibody
Membrane protein antibody
Oral cancer overexpressed protein 2 antibody
ORAOV 2 antibody
TAOS2 antibody
Transmembrane protein 16A antibody
Tumor-amplified and overexpressed sequence 2 antibody
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TMEM16A Antibody FITC
TMEM16A Antibody BIOTIN
TMEM16A Blocking Peptide
TMEM16A Positive Control
