General Information

Product

Fbx32 Antibody

Description

Affinity Purified Atrogin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse

Immunogen

Synthetic peptide taken within amino acid region 240-280 on Atr1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q969P5

Overview

Substrate recognition component of a SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Molecular Function

Ubl conjugation pathway

Subcellular Location

Cytoplasm; Nucleus

Expression

Cardiac and skeletal muscle

Structure

Contains 1 F-box domain

Alternative Nomenclature

Atrophy gene 1 antibody

F-box only protein 32 antibody

fbxo25 antibody

Muscle atrophy F-box protein antibody

General Information

Product

BMP8 Antibody

Description

Affinity Purified Bone morphogenetic protein 8 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 160-200 on human BMP8 protein

Accession #

NCBI:  CAB75681

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

P34820

Overview

Induces cartilage and bone formation.

Molecular Function

Chondrogenesis; Differentiation; Osteogenesis

Subcellular Location

Secreted

Structure

Homodimer; Disfulfide-linked

Alternative Nomenclature

OP 2 antibody

Osteogenic protein 2 antibody BMP-8 antibody

dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)) antibody

Osteogenic protein 2 antibody

General Information

Product

Glucose transporter GLUT4 Antibody

Description

Affinity Purified Solute carrier family 2 , facilitated glucose transporter member 4 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-509 on mouse Solute carrier family 2, facilitated glucose transporter member 4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DOT Blot

1:4,000

ELISA

1:4,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:1,000

Protein

Uniprot #

P14142

Overview

Insulin-regulated facilitative glucose transporter

Molecular Function

glucose transmembrane transporter activity;insulin-responsive hydrogen:glucose symporter activity

Subcellular Location

Cell membrane, Cytoplasm, Membrane

Expression

Skeletal and cardiac muscles; brown and white fat.

Structure

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily

Alternative Nomenclature

insulin-responsive antibody

Glucose transporter GLUT 4 antibody

GLUT 4 antibody

kug antibody

SLC 2A4 antibody

Solute carrier family 2, facilitated glucose transporter member 4 antibody

General Information

Product

OSR2 Antibody

Description

Affinity Purified Protein Odd-Skipped-Related 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 90-250 on mouse Osr2 protein.

Accession #

NCBI:  NP_473390.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q91ZD1

Molecular Function

Metal ion binding

Subcellular Location

Nucleus

Alternative Nomenclature

FLJ90037 antibody

Odd skipped related 2 antibody

Odd skipped related 2A protein antibody

odd-skipped related 2 (Drosophila) antibody

Osr2 antibody

OSR2_HUMAN antibody

Protein odd-skipped-related 2 antibody

General Information

Product

p75 NGF Receptor Antibody

Description

Affinity Purified p75 neurotrophin receptor a-2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Immunogen

Synthetic peptide corresponding to unique N-terminus amino acid sequence on P-75NTR protein.

Accession #

GenBank: AAD51031.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9PRG7

Molecular Function

Receptor

Alternative Nomenclature

CD271 antibody

CD271 antigen antibody

Gp80 LNGFR antibody

Low affinity nerve growth factor receptor antibody

Nerve growth factor receptor antibody

NGF receptor antibody

NGFR antibody

p75 ICD antibody

p75 Neurotrophin receptor antibody

p75 NTR antibody

TNFR Superfamily Member 16 antibody

TNFRSF16 antibody

General Information

Product

PAX3 Antibody

Description

Affinity Purified Paired Box Protein Pax-3 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PAX3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.64-.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P23760

Overview

Is a transcription factor that may regulate cell proliferation, migration and apoptosis.  Plays a role in neural development and myogenesis.

Molecular Function

Developmental protein, chromatin binding, sequence-specific DNA binding

Subcellular Location

Nucleus

Structure

Capable of binding to DNA as a homodimer or a heterodimer with PAX7.  Interacts with DAXX and TBX18.

Alternative Nomenclature

CDHS antibody

HUP 2 antibody

MGC120381 antibody

MGC120382 antibody

MGC120383 antibody

MGC120384 antibody

MGC134778 antibody

Paired box 3 antibody

paired box homeotic gene 3 antibody

paired domain gene 3 antibody

PAX 3 antibody

PAX3/FKHR fusion gene antibody

Waardenburg syndrome 1 antibody

WS 1 antibody

WS3 antibody

General Information

Product

ROR2 Antibody

Description

Affinity Purified Tyrosine-protein kinase transmembrane receptor ROR2 precursor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-943 on human ROR2 protein.

Accession #

NCBI:  NP_004551.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q01974

Overview

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.

Molecular Function

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass type 1 membrane  protein

Expression

Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

Structure

Homodimer; promotes osteogenesis. Binds YWHAB. Interacts with WTIP.

Alternative Nomenclature

BDB antibody

BDB1 antibody

Brachydactyly type B antibody

EC 2.7.10.1 antibody

MGC163394 antibody

Neurotrophic tyrosine kinase, receptor related 2 antibody

NTRKR2 antibody

Receptor tyrosine kinase-like orphan receptor 2 antibody

General Information

Product

RUNX2 Antibody

Description

Affinity Purified Runt-related transcription factor 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Synthetic peptide taken within amino acid region 10-50 on human RUNX2 protein.

Accession #

NCBI:  XP_001100855.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI0000D9AD12

Overview

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.

Molecular Function

DNA-binding; Transcription Regulation

Subcellular Location

Nucleus

Structure

Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with HIVEP3. Interacts with IFI204. I

Alternative Nomenclature

Acute myeloid leukemia 3 protein antibody

Alpha subunit 1 antibody

AML3 antibody

CBF alpha 1 antibody

CBFA1 antibody

CCD1 antibody

Cleidocranial dysplasia 1 antibody

Core binding factor runt domain alpha subunit 1 antibody

Core binding factor subunit alpha 1 antibody

Oncogene AML 3 antibody

OSF 2 antibody

Osteoblast specific transcription factor 2 antibody

PEBP2 alpha A antibody

PEBP2A1 antibody

PEBP2A2 antibody

Polyomavirus enhancer-binding protein 2 alpha A subunit antibody

Runt domain antibody

Runt related transcription factor 2 antibody SL3 3 enhancer factor 1 alpha A subunit antibody

General Information

Product

SFRP2 Antibody 

Description

Affinity Purified Secreted frizzled-related protein 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 225-295 on human SFRP2.

Accession #

GenBank: AAH08666.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q96HF1

Overview

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

Molecular Function

Endopeptidase activator activity, integrin binding, PDZ domain binding, Wnt-activated receptor activity, fibronectin binding, receptor agonist activity, Wnt-protein binding

Subcellular Location

Secreted

Expression

Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.

Alternative Nomenclature

AI851596 antibody
Frizzled related protein 2 antibody
FRP2 antibody
SARP1 antibody
SDF5 antibody
Secreted apoptosis related protein 1 antibody
Secreted frizzled-related protein 2 antibody

General Information

Product

Bestrophin 1 Antibody

Description

Affinity Purified Bestrophin 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Dog, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 530-580 on canine Bestrophin 1 protein.

Accession #

NCBI:  NP_001091014.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

A5H7G8

Overview

Forms calcium sensitive chloride channels. Highly permeable to bicarbonate.

Molecular Function

Ion transport; Sensory transduction; Transport; Vision

Subcellular Location

Cell membrane; Multi-pass membrane protein; Basolateral cell membrane

Expression

Predominantly expressed in the basolateral membrane of the retinal pigment epithelium

Structure

Tetramer or pentamers

Alternative Nomenclature

ARB antibody

BEST 1 antibody

BEST antibody

Best disease antibody

Best macular dystrophy antibody

Best1V1Delta2 antibody

BMD antibody

mBest1 antibody

RP50 antibody

TU15B antibody

Vitelliform macular dystrophy 2 antibody

Vitelliform macular dystrophy protein 2 antibody

VMD 2 antibody