General Information

Product

Natriuretic Peptide Receptor C Antibody 

Description

Affinity Purified Atrial natriuretic peptide receptor 3 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 490-540 on bovine Atrial natriuretic peptide receptor 3 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1;10,000

ELISA

1;10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P10730

Overview

osteoclast proliferation;regulation of blood pressure;skeletal system development

Molecular Function

natriuretic peptide receptor activity

Subcellular Location

Membrane

Structure

Homodimer; disulfide-linked

Alternative Nomenclature

ANP C antibody

ANPR-C antibody

Atrial natriuretic peptide C type receptor antibody

C5orf23 antibody

FLJ14054 antibody

GUCY2B antibody

MGC22189 antibody

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) antibody

NPR 3 antibody

NPR C antibody

General Information

Product

OCSTAMP Antibody

Description

Affinity Purified Osteoclast stimulatory transmembrane protein Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 within second intracellular loop of human OC-STAMP protein.

Accession #

NCBI: NP_542452.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9BR26

Overview

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation;Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation.

Subcellular Location

Membrane

Expression

testis

Alternative Nomenclature

OTTHUMP00000031209 antibody

RP11-179N14.1 antibody

zfp334 antibody

zinc finger protein 334 antibody

Thyrotropin hormone releasing receptor like antibody

C20orf123

Chromosome 20 open reading frame 123

ZNF334

General Information

Product

OSR2 Antibody

Description

Affinity Purified Protein Odd-Skipped-Related 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 90-250 on mouse Osr2 protein.

Accession #

NCBI:  NP_473390.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.51-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q91ZD1

Molecular Function

Metal ion binding

Subcellular Location

Nucleus

Alternative Nomenclature

FLJ90037 antibody

Odd skipped related 2 antibody

Odd skipped related 2A protein antibody

odd-skipped related 2 (Drosophila) antibody

Osr2 antibody

OSR2_HUMAN antibody

Protein odd-skipped-related 2 antibody

General Information

Product

Punt Antibody

Description

Affinity Purified Punt receptor Serine/Threonine kinase (punt) Antibody

Verified Applications

ELISA, ICC, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Synthetic peptide corresponding to C terminal amino acids 497-515 of Drosophila melanogaster PUNT protein. Peptides were amidated for conjugation.

Sequence:

QLLIKNHTNIDDAKESTNC

Accession #

GenBank: L38495.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q24468

Overview

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Molecular Function

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Subcellular Location

Activin receptor complex, Plasma membrane

Structure

Contains protein kinase domain.

Alternative Nomenclature

Activin A receptor 88CD antibody
Activin receptor type II antibody
Atr antibody
Atr88CD antibody
AtrII antibody
dlhC antibody
Dorsal holes C antibody
j5A5 antibody
Pun antibody
Put antibody
STKC antibody
TGF beta l antibody
TGF beta type receptor like antibody
Tgf r antibody

General Information

Product

Punt Antibody

Description

Affinity Purified Punt receptor Serine/Threonine kinase (punt) Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

N-epitope synthetic peptide corresponding to unique amino acid sequences on D. melanogaster Punt protein.

Accession #

GenBank: L38495.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q24468

Overview

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Molecular Function

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Subcellular Location

Activin receptor complex, Plasma membrane

Structure

Contains protein kinase domain.

Alternative Nomenclature

Activin A receptor 88CD antibody
Activin receptor type II antibody
Atr antibody
Atr88CD antibody
AtrII antibody
dlhC antibody
Dorsal holes C antibody
j5A5 antibody
Pun antibody
Put antibody
STKC antibody
TGF beta l antibody
TGF beta type receptor like antibody
Tgf r antibody

General Information

Product

Osteocalcin Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Pig

Predicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 50-100 on human Osteocalcin preprotein.

Accession #

NCBI:  NP_954642.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P02818

Overview

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Molecular Function

Calcium ion binding; Hydroxyapatite binding; Structural constituent of bone; Structural molecule activity

Subcellular Location

Secreted

Structure

Belongs to the osteocalcin/matrix Gla protein family. Contains 1 Gla (gamma-carboxy-glutamate) domain.

Alternative Nomenclature

BGLAP antibody

BGP antibody

Bone gamma carboxyglutamate gla protein osteocalcin antibody

Bone Gla protein antibody

Gamma carboxyglutamic acid containing protein antibody

OC antibody

OCN antibody

OSTCN_HUMAN antibody

Osteocalcin antibody

PMF1 antibody

General Information

Product

Osteoprotegerin Antibody

Description

Affinity Purified Tumor necrosis factor receptor superfamily member 11B Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human Predicted Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-400 on human Tumor necrosis factor receptor superfamily member 11B protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O00300

Overview

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

Molecular Function

Receptor

Subcellular Location

Secreted

Expression

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Structure

Contains 2 death domains.

Contains 4 TNFR-Cys repeats.

Alternative Nomenclature

OCIF antibody

OPG antibody

Osteoclastogenesis inhibitory factor antibody

Osteoprotegerin antibody

TNFRSF 11B antibody

TR1 antibody

Tumor necrosis factor receptor superfamily member 11B antibody

General Information

Product

Legumain Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Legumain protein.

Accession #

NCBI:  XP_016876954

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q99538

Overview

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Subcellular Location

Lysosome

Expression

Ubiquitous. Particularly abundant in kidney, heart and placenta.

Structure

In the zymogen form, the uncleaved propeptide blocks access to the active site.

Alternative Nomenclature

AEP antibody
Asparaginyl endopeptidase antibody
cysteine 1 antibody
Cysteine protease 1 antibody
Legumain antibody
LGMN antibody
LGMN1 antibody
Protease antibody
Protease cysteine 1 (legumain) antibody
Protease cysteine 1 antibody
PRSC1 antibody