General Information

Product

Glucose transporter GLUT2 Antibody

Description

Affinity Purified Solute carrier family 2, facilitated glucose transporter member 2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino accid region 473-523 on mouse GLUT2 protein.

Accession #

NCBI:  NP_112474.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:8,000

ELISA

1:8,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P19357

Overview

Insulin-regulated facilitative glucose transporter.

Molecular Function

glucose transmembrane transporter activity

Subcellular Location

Cell membrane, Cytoplasm, Membrane

Expression

Skeletal and cardiac muscles; brown and white fat.

Structure

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Alternative Nomenclature

liver antibody

Glucose Transporter 2 antibody

Glucose transporter type 2 liver antibody

Glucose transporter, liver/islet antibody

GLUT2 antibody

GTT2 antibody

SLC2A2 antibody

Solute carrier family 2 (facilitated glucose transporter) member 2 antibody

General Information

Product

Soluble Adenylate Cyclase 10 Antibody

Description

Affinity Purified Bicarbonate activated soluble adenylate cyclase 10 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Gorilla, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse Adenylate Cyclase type 10 protein.

Accession #

NCBI:  NP_766617.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q8C0T9

Overview

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.

Molecular Function

Adenylate cyclase activity; ATP binding; Magnesium ion binding; Manganese ion binding

Subcellular Location

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Expression

Expressed in testis.

Structure

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Alternative Nomenclature

3',5'-cyclic AMP synthetase antibody

Adenylate cyclase 10 (soluble) antibody

AH related protein antibody

ATP pyrophosphate-lyase antibody

Germ cell soluble adenylyl cyclase antibody

HCA2 antibody

hsAC antibody

hypercalciuria absorptive antibody

SAC antibody

SACI antibody

Sacy antibody

Soluble adenylyl cyclase antibody

Testicular soluble adenylyl cyclase antibody

General Information

Product

Phospho-AKT1 Antibody

Description

Affinity Purified Phosphorylated Rac protein kinase-alpha Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bird, Bovine, Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 430-480 on human Rac protein kinase-alpha protein.

Accession #

GenBank: AAA36539.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P31749

Overview

One of 3 serine/threonine-protein kinases (AKT1-AKT3) regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis.

Molecular Function

Developmental protein; Kinase; Serine/threonine-protein kinase; Transferase

Subcellular Location

Cytoplasm; Nucleus; Cell membrane

Expression

Expressed in prostate cancer and all human cell types.

Structure

Interacts with and phosphorylated by PDPK1.  Interacts with several proteins invovled in phosphorylation and ubiquitination

Alternative Nomenclature

AKT 1 antibody

C AKT antibody

MGC9965 antibody

MGC99656 antibody

Oncogene AKT1 antibody

PKB antibody

PKB-ALPHA antibody

PRKBA antibody

Protein Kinase B Alpha antibody

Protein kinase B antibody

Proto-oncogene c-Akt antibody

RAC Alpha antibody

RAC antibody

RAC PK Alpha antibody

RAC Serine/Threonine Protein Kinase antibody

RAC-PK-alpha antibody

vAKT Murine Thymoma Viral Oncogene Homolog 1 antibody

General Information

Product

RACK1 Antibody

Description

Affinity Purified Receptor for activated C kinase Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Arabidopsis thaliana

Immunogen

Synthetic peptide taken within amino acid region 250-300 on A. thaliana RACK1A protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O24456

Overview

Major component of the RACK1 regulatory proteins that play a role in multiple signal transduction pathways. Involved in multiple hormone responses and developmental processes (PubMed:16829549, PubMed:18715992, PubMed:18947417). MAPK cascade scaffolding protein involved in the protease IV and ArgC signaling pathway but not the flg22 pathway (PubMed:25731164).

Molecular Function

Transducer; Ribosome Biogenesis; Protein Complex Scaffold

Subcellular Location

Cytoplasm; Nucleus

Expression

Widely Expressed

Structure

Belongs to the WD repeat G protein beta family. Contains 7 WD repeats.

Alternative Nomenclature

Cell proliferation-inducing gene 21 protein antibody

Gnb2-rs1 antibody

Guanine nucleotide binding protein (G protein) beta polypeptide 2 like 1 antibody

HLC 7 antibody

Human lung cancer oncogene 7 protein antibody

PIG21 antibody

Proliferation inducing gene 21 antibody

Protein homologous to chicken B complex protein guanine nucleotide binding antibody

RACK 1 antibody

Receptor for activated C kinase 1 antibody

General Information

Product

Glucose Transporter GLUT3 Antibody

Description

Affinity Purified Solute carrier family 2, facilitated glucose transporter member 3 Antibody

Verified Applications

CM, ELISA, Flow cytometry, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-493 on mouse SLC2A3 protein.

Accession #

NCBI: NP_008862

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confotcal Microscopy

1:250

DOT Blot

1:25,000

ELISA

1:25,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:200

Western Blot

1:8,000

Protein

Uniprot #

Q4FJP8

Overview

Facilitative glucose transporter.

Molecular Function

Sugar Transport

Subcellular Location

Membrane; Multi-pass membrane protein

Expression

Brain and many other tissues.

Structure

Transmembrane helix

Alternative Nomenclature

brain antibody

FLJ90380 antibody

Glucose transporter type 3 brain antibody

GLUT-3 antibody

SLC2A3 antibody

Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 3 antibody

General Information

Product

LAMP2 Antibody

Description

Affinity Purified Lysosome-associated membrane glycoprotein 2 Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Predicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 260-310 on human lysosomal membrane glycoprotein-2.

Accession #

GenBank: AAB41647.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P13473

Overview

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion

Molecular Function

enzyme binding

Subcellular Location

Cell membrane, Endosome, Lysosome, Membrane

Expression

LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle.LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

Structure

Belongs to the LAMP family

Alternative Nomenclature

CD107 antigen-like family member B antibody

CD107b antibody

LAMP 2 antibody

LAMP 2C antibody

LAMPB antibody

LGP110 antibody

Lysosome associated membrane protein 2 antibody

MAC3 antibody

General Information

Product

NPY1R Antibody

Description

Affinity Purified Neuropeptide Y receptor type 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on NPY1R protein.

Accession #

NCBI: NP_001106828.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

G3V7T1

Overview

regulation of blood pressure;regulation of multicellular organism growth;glucose metabolic process

Molecular Function

G-protein coupled receptor

Subcellular Location

Membrane

Expression

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y receptor type 1 antibody

NPY1R antibody

NPYR antibody

NPYY1 antibody

General Information

Product

NAK Antibody

Description

Affinity Purified Serine/Threonine-protein kinase TBK1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within second intracecllular loop of human TBK1 protein.

Accession #

NCBI:  NP_037386

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9UHD2

Overview

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.

Molecular Function

ATP binding; Nucleic acid binding; Protein serine/threonine kinase activity

Subcellular Location

Cytoplasm

Expression

Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina.

Structure

Homodimer

Alternative Nomenclature

NAK antibody

NF kappa B activating kinase antibody

Serine/threonine protein kinase TBK 1 antibody

T2K antibody

TANK antibody

TANK binding kinase 1 antibody

TBK 1 antibody

TRAF2 antibody

TRIF antibody

General Information

Product

SIGLEC10 Antibody

Description

Affinity Purified Sialic acid-binding Ig-like lectin 10 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 650-697 on human SIGLEC10 protein.

Accession #

NCBI:  NP_149121.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.60 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q96LC7

Overview

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Molecular Function

carbohydrate binding

Subcellular Location

Isoform 1,2,3,4: cell membrane, single-pass type I membrane protein; isoform 5: secreted

Expression

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Alternative Nomenclature

PRO940 antibody

sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody

Sialic acid binding Immunoglobulin like lectin 10 antibody

SIGLEC 10 antibody

Siglec G antibody

Siglec-like protein 2 antibody

SIGLEC10 antibody

Siglecg antibody

SLG2 antibody

General Information

Product

SIRT7 Antibody

Description

Affinity Purified Sirtuin (silent mating type information regulation 2 homolog) 7 Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-400 on mouse SIRT7 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BKJ9

Overview

NAD-dependent protein deacetylase that specifially mediates deacetylation of histone H3 at 'Lys-18'. Displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression.

Molecular Function

Chromatin binding, NAD+ binding, NAD-dependent histone deacetylase activity (H3-K18 specific), metal ion binding

Subcellular Location

Cytoplasm, nucleus, nucleolus. (Note: Located close to the nuclear membrane when in cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Expression

Detected in liver, spleen and testis. Detected in embryos.

Structure

Belongs to the Sirtuin Family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain.

Alternative Nomenclature

NAD dependent deacetylase sirtuin 7 antibody

Regulatory protein SIR2 homolog 7 antibody

Silent mating type information regulation 2 homolog antibody

SIR2 L7 antibody

SIR2 like protein 7 antibody

Sir2 related protein type 7 antibody

SIRT7 antibody

Sirtuin 7 antibody

Sirtuin type 7 antibody