Ephrin Receptor A3 Antibody

General Information

Product

Ephrin Receptor A3 Antibody

Description

Affinity Purified Ephrin Type-A Receptor 3 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-980 on human EPHA3 protein

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P29320

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

Molecular Function

ATP binding; Nucleotide binding

Subcellular Location

Isoform 1:  Cell membrane; Single-pass type I membrane protein.  Isoform 2:  Secreted

Expression

Widely expressed. Highest level in placenta.

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding.

Alternative Nomenclature

AW492086 antibody

Cek4 antibody

EC 2.7.10.1 antibody

EK4 antibody

End3 antibody

Eph receptor A3 antibody

EPH-like kinase 4 antibody

EPH-like tyrosine kinase 1 antibody

EphA3 antibody

Ephrin type-A receptor 3 antibody

ETK 1 antibody

ETK antibody

HEK 4 antibody

HEK antibody

Human embryo kinase 1 antibody

Mek4 antibody

MGC109882 antibody

Receptor tyrosine kinase HEK antibody

Tyro 4 antibody

Tyrosine-protein kinase TYRO4 antibody