General Information
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Product
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Eprhin Receptor A5 Antibody Affinity Purified
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Description
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Affinity Purified Ephrin Type-1 Receptor isoform a Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 600-700 on human EphA R5 protein.
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Accession #
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NCBI: NP_004430
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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P54756
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Overview
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Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
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Molecular Function
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ATP-binding, Nucleotide-binding
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Subcellular Location
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Membrane; Single-pass type I membrane protein
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Expression
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Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
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Structure
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Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).
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Alternative Nomenclature
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Brain-specific kinase antibody
bsk antibody
CEK 7 antibody
Eck like sequence 1 antibody
EHK 1 antibody
EK7 antibody
Els 1 antibody
Eph homology kinase 1 antibody
EPH-like kinase 7 antibody
EphA5 antibody
Ephrin type-A receptor 5 antibody
HEK 7 antibody
Rek 7 antibody
TYRO 4 antibody
Tyrosine protein kinase receptor EHK 1 antibody
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