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General Information
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Product
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Eprhin Receptor B3 Antibody Affinity Purified
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Description
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Affinity Purified Ephrin type-B receptor 3 precursor Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 100-200 on EphBR3 protein.
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Accession #
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NCBI: NP_034273
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.58-0.61 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:750
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Protein
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Uniprot #
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P54754
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Overview
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Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
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Molecular Function
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ATP-binding, Nucleotide-binding
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Subcellular Location
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Cell membrane; Single-pass type I membrane protein; Early endosome membrane; Dendrite
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Expression
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Expressed in cells of the retinal ganglion cell layer during retinal axon guidance to the optic disk. Expressed by Paneth and progenitor cells in the crypts of the intestinal epithelium (at protein level).
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Structure
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Contains 1 Eph LBD domain; Contains 2 fibronectin type-III domains; Contains 1 protein kinase domain; Contains 1 SAM domain
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Alternative Nomenclature
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Cek10 antibody
EK2 antibody
Embryonic kinase 2 antibody
EPH Like Tyrosine Kinase 2 antibody
EPH receptor B3 antibody
EPH-like kinase 2 antibody
ephb3 antibody
Ephrin type-B receptor 3 antibody
ETK2 antibody
hEK2 antibody
Human Embryo Kinase 2 antibody
Mdk5 antibody
Sek4 antibody
TYRO6 antibody
Tyrosine protein kinase receptor HEK2 antibody
Tyrosine-protein kinase TYRO6 antibody
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Ephrin Receptor B3 Antibody FITC
Ephrin Receptor B3 Antibody BIOTIN
Ephrin Receptor B3 Blocking Peptide
Ephrin Receptor B3 Positive Control
