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General Information
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Product
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Eprhin Receptor B4 Antibody
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Description
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Affinity Purified Ephrin type-B receptor 4 precursor Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human
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Immunogen
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Synthetic peptide taken within amino acid region 900-984 on human Ephrin B4 receptor protein.
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Accession #
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NCBI: NP_004435
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.62 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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1:200 |
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Western Blot
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1:500
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Protein
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Uniprot #
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P54760
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Overview
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Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
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Molecular Function
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ATP-binding, Nucleotide-binding
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Subcellular Location
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Cell Membrane
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Expression
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Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix.
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Structure
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Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.
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Alternative Nomenclature
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Ephb4 antibody
Ephrin type-B receptor 4 antibody
Hepatoma Transmembrane Kinase antibody
HTK antibody
MYK 1 antibody
MYK1 antibody
TYRO 11 antibody
Tyrosine-protein kinase receptor HTK antibody
Tyrosine-protein kinase TYRO11 antibody
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Ephrin Receptor B4 Antibody FITC
Ephrin Receptor B4 Antibody BIOTIN
Ephrin Receptor B4 Blocking Peptide
Ephrin Receptor B4 Positive Control
