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General Information
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Product
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Inhibin alpha Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated Inhibin alpha chain Antibody Mixed Epitope
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptides corresponding to amino acid region taken within 1-50 and 220-270 on Inhibin alpha gene.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.52-0.75 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Determinant
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Mixed Epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:20,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P05111
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Overview
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Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.
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Molecular Function
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Cytokine activity, hormone activity, growth factor activity, receptor binding
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Subcellular Location
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Secreted
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Expression
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Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.
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Alternative Nomenclature
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A inhibin subunit antibody
IHA antibody
inhA antibody
INHA_HUMAN antibody
Inhibin alpha chain antibody
Inhibin alpha subunit antibody
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Inhibin alpha Antibody
Inhibin alpha Antibody FITC
Inhibin alpha Blocking Peptide
Inhibin alpha Positive Control
