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General Information
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Product
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MAPK4 Antibody
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Description
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Affinity Purified Mitogen-activated protein kinase 4 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Chicken
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 500-550 on human Mitogen-activated protein kinase 4.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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P31152
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Overview
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Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Nucleus
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Expression
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High expression in heart and brain.
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Structure
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Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5.
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Alternative Nomenclature
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ERK-4 antibody
Extracellular signal-regulated kinase 4 antibody
MAP kinase 4 antibody
MAP kinase isoform p63 antibody
MAPK4 antibody
p63 MAPK antibody
PRKM4 antibody
Protein kinase, mitogen-activated, 4 antibody
Protein-tyrosine kinase ERK3-related antibody
RMNK2 antibody
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MAPK4 Antibody BIOTIN
MAPK4 Antibody FITC
MAPK4 Blocking Peptide
MAPK4 Positive Control
