MAPK4 Positive Control

General Information

Product

MAPK4 Positive Control

Description

Western Blot Positive Control Mitogen-activated protein kinase 4 Antibody

Verified Applications

WB

Immunogen

Purified protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P31152

Overview

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Nucleus

Expression

High expression in heart and brain.

Structure

Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5.

Alternative Nomenclature

ERK-4 antibody
Extracellular signal-regulated kinase 4 antibody
MAP kinase 4 antibody
MAP kinase isoform p63 antibody

MAPK4 antibody

p63 MAPK antibody

PRKM4 antibody
Protein kinase, mitogen-activated, 4 antibody
Protein-tyrosine kinase ERK3-related antibody
RMNK2 antibody