Apelin Receptor Blocking Peptide

General Information

Product

Apelin Receptor Peptide

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 150-200 human Apelin receptor protein.

Accession #

NCBI:  NP_005152

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P35414

Overview

Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.

Molecular Function

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Multi-pass membrane protein

Expression

Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.

Structure

Transmembrane, Transmembrane helix

Alternative Nomenclature

AGTRL1 ligand antibody

APEL antibody

Apelin-13 antibody

APJ endogenous ligand antibody

Apln antibody

XNPEP2 antibody