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General Information
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Product
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BMP2 Peptide
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Description
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Antigenic Blocking Peptide Bone morphogenetic Protein 2 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide description
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Synthetic peptide corresponding to amino acids within region 340-396 on human Bone morphogenetic Protein 2.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Purification Method
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Immobilized antigen affinity chromatography
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Storage
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-20?C for long term storage
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Application Protocol
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Immunodepletion, Immunocompetition
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Refer to competition assay protocol
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Protein
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Uniprot #
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P12643
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Overview
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Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
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Molecular Function
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BMP receptor binding
co-receptor binding
cytokine activity
growth factor activity
phosphatase activator activity
retinol dehydrogenase activity
signaling receptor binding
SMAD binding
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Subcellular Location
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Secreted
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Expression
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Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
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Structure
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Belongs to the TGF-beta family.
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Alternative Nomenclature
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BDA2 antibod
BMP 2 antibody
BMP 2A antibody
BMP-2 antibody
BMP-2A antibody
Bmp2 antibody
BMP2_HUMAN antibody
BMP2A antibody
Bone morphogenetic protein 2 antibody
Bone morphogenetic protein 2A antibody
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BMP2 Antibody
BMP2 Antibody BIOTIN
BMP2 Antibody FITC
BMP2 Positive Control
