BMP2 Positive Control

General Information

Product

BMP2 Positive Control

Description

Western Blot Positive Control Bone morphogenetic Protein 2 Antibody

Verified Applications

WB

Physical Properties

Quantity

5 Applications

Volume

Inquire

Concentration

The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel.

Form

Western Blot Positive Control

Storage

-20?C for long term storage

Protein

Uniprot #

P12643

Overview

Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).

Molecular Function

BMP receptor binding

co-receptor binding

cytokine activity

growth factor activity

phosphatase activator activity

retinol dehydrogenase activity

signaling receptor binding

SMAD binding

Subcellular Location

Secreted

Expression

Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Structure

Belongs to the TGF-beta family.

Alternative Nomenclature

BDA2 antibod

BMP 2 antibody

BMP 2A antibody

BMP-2 antibody

BMP-2A antibody

Bmp2 antibody

BMP2_HUMAN antibody

BMP2A antibody

Bone morphogenetic protein 2 antibody

Bone morphogenetic protein 2A antibody