BMPR1A Blocking Peptide

General Information

Product

BMPR1A Peptide

Description

Antigenic Blocking Peptide Bone morphogenetic protein receptor type-1A

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 460-510 on human Bone morphogenetic protein receptor type-1A.

Accession #

NCBI:  NP_004320

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

1:500

Protein

Uniprot #

P36894

Overview

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.

Molecular Function

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Highly expressed in skeletal muscle.

Structure

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Alternative Nomenclature

Activin A receptor type II like kinase 3 antibody

Activin receptor like kinase 3 antibody

ACVRLK 3 antibody

ALK 3 antibody

BMP type-1A receptor antibody

BMPR 1A antibody

Bmpr antibody

Bone morphogenetic protein receptor type-1A antibody

BR1a antibody

CD292 antibody

Serine threonine protein kinase receptor R5 antibody

SKR5 antibody

zBMPR IA antibody