ELOVL1 Blocking Peptide

General Information

Product

ELOVL1 Peptide

Description

Antigenic Blocking Peptide Elongation of very long chain fatty acids protein 1

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 148-198 on human Elongation of very long chain fatty acids protein 1.

Accession #

NCBI:  NP_001243331

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q9BW60

Overview

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.

Molecular Function

Transferase; Fatty acid biosynthesis & metabolism; Lipid biosynthesis & metabolism

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Ubiquitous

Structure

The di-lysine motif may confer endoplasmic reticulum localization.

Alternative Nomenclature

3 keto acyl CoA synthase ELOVL1 antibody

CGI 88 antibody

Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 1 antibody

Elongation of very long chain fatty acids protein 1 antibody

ELOVL 1 antibody

ELOVL FA elongase 1 antibody

ELOVL fatty acid elongase 1 antibody

ELOVL1 antibody

Ssc1 antibody

Very-long-chain 3-oxoacyl-CoA synthase 1 antibody