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General Information
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Product
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GRK6 Peptide
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Description
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Antigenic Blocking Peptide G protein-coupled receptor kinase 6
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.
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Accession #
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NCBI: NP_002073
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P43250
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Overview
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Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
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Molecular Function
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ATP binding
beta-adrenergic receptor kinase activity
G-protein coupled receptor kinase activity
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Subcellular Location
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Membrane; Lipid-anchor
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Expression
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Widely expressed.
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Structure
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Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
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Alternative Nomenclature
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G protein coupled receptor kinase 6 antibody
G protein coupled receptor kinase GRK6 antibody
Gprk6 antibody
Grk6 antibody
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GRK6 Antibody
GRK6 Antibody BIOTIN
GRK6 Antibody FITC
GRK6 Positive Control
