IRE1 Blocking Peptide

General Information

Product

IRE1 Peptide

Description

Antigenic Blocking Peptide Serine/Threonine-protein kinase/endoribonuclease IRE1 Antibody

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide corresponding to unique amino acid sequence within amino acid region 900-977 on human IRE1A protein.

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

O75460

Overview

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Molecular Function

Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type 1 membrane protein

Expression

Ubiquitously expressed. High levels observed in pancreatic tissue.

Structure

Interacts with DAB2IP (via PH domain); the interaction occurs in a ER stress-induced dependent manner and is required for subsequent recruitment of TRAF2 to ERN1 (By similarity). Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic intera

Alternative Nomenclature

Endoplasmic reticulum (ER) to nucleus signalling 1 antibody Endoribonuclease antibody
ER to nucleus signaling 1 antibody

ERN 1 antibody

hIRE 1p antibody
Inositol requiring 1 antibody
Inositol requiring protein 1 antibody
IRE 1 antibody
IRE 1a antibody
IRE 1P antibody
Ire1 alpha antibody

IRE1P antibody
MGC163277 antibody
MGC163279 antibody
Protein kinase/endoribonuclease antibody
RGD1559716 antibody
Serine/threonine protein kinase/endoribonuclease IRE1 antibody