IP3 receptor Blocking Peptide

General Information

Product

IP3 receptorPeptide

Description

Antigenic Blocking Peptide Inositol 1,4,5-trisphosphate receptor type  isoform 1

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide

Accession #

NCBI:  NP_001093422.2

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q14643

Overview

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Molecular Function

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Widely expressed

Structure

Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe

Alternative Nomenclature

5-trisphosphate receptor antibody

DKFZp313N1434 antibody

inositol 1 4 5 triphosphate receptor type 1 antibody

Inositol 1 antibody

InsP3R1 antibody

IP3 antibody

IP3 receptor antibody

IP3R1 antibody

ITPR 1 antibody

SCA15 antibody

SCA16 antibody

SCA29 antibody

Type 1 inositol 1 4 5 trisphosphate receptor antibody

Type 1 inositol 1 antibody