PDE11A Blocking Peptide

Product no.: P-PD11A.112

$155.00

Description
Publications

General Information
Product	PDE11A Peptide
Description	Antigenic Blocking Peptide Cyclic Nucleotide Phosphodiesterase 11A1 C-epitope
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	Synthetic peptide taken within amino acid region 420-480 on PDE11A protein, common to all PDE11A variants.
Accession #	GenBank: CAB82573.1
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Determinant	C-epitope
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	Q9HCR9
Overview	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Molecular Function	Hydrolase, metal-ion binding, cGMP binding
Subcellular Location	Cytoplasm
Expression	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil is not relevant (at protein level). Isoform 2 may be expressed in testis.
Alternative Nomenclature	5''-cyclic-AMP and -GMP phosphodiesterase 11A cAMP and cGMP cyclic nucleotide phosphodiesterase 11A Cyclic nucleotide phosphodiesterase 11A1 Dual 3' 5' cyclic AMP and GMP phosphodiesterase 11A PDE 11A pde11 pde11a2 Phosphodiesterase 11A PPNAD2

Protein information supplied by UniProt

Fabgennix PDE11A Antibody has been used in 14 Publications
P Kelly, Michy. "Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?." Current pharmaceutical design 21.3 (2015): 389-416. PMID25159071	Western Blot; Rat
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the Human ovary." Molecular and cellular endocrinology (2015). PMID25578602	Immunohistochemistry, Immunocompetition; Human
Kelly, Michy P., et al. "Select 3′, 5′-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." Cellular signalling 26.2 (2014): 383-397.PMID24184653	Western Blot Immunocompetition; Human, Mouse
Hamilton, Thomas K., et al. "Potential therapeutic applications of phosphodiesterase inhibition in prostate cancer." World journal of urology 31.2 (2013): 325-330.PMID22383129	Western Blot; Human
Ückert, Stefan, et al. "Expression and distribution of phosphodiesterase isoenzymes in the Human seminal vesicles." The journal of sexual medicine 8.11 (2011): 3058-3065. PMID21810184	Immunohistochemistry; Human
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350.PMID21653225	Immunofluorescence, Western Blot; Rat
Ückert, S, et al. "Expression And Distribution Of Key Enzymes Of The Cyclic GMP Signaling In The Human Clitoris: Relation To Phosphodiesterase Type 5 (PDE5)." International Journal Of Impotence Research 23.5 (2011): 206-212. PMID21697861	Immunohistochemistry; Human
Kelly, Michele P. et al. “Phosphodiesterase 11A in Brain Is Enriched in Ventral Hippocampus and Deletion Causes Psychiatric Disease-Related Phenotypes.”Proceedings of the National Academy of Sciences of the United States of America 107.18 (2010): 8457–8462. PMC2889541	Western Blot; Mouse
Kruse, Lars S., et al. "PDE9A, PDE10A, and PDE11A expression in Rat trigeminovascular pain signalling system." Brain research 1281 (2009): 25-34. PMID19445908	Immunohistochemistry, Immunodepletion, Western Blot; Rat
Ückert, Stefan, et al. "Immunohistochemical Description of Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Labia Minora." The Journal of Sexual Medicine 4.3 (2007): 602-608. PMID17498099	Immunofluorescence; Human
Ückert, Stefan, et al. "Immunohistochemical distribution of cAMP-and cGMP-phosphodiesterase (PDE) isoenzymes in the Human prostate." European urology 49.4 (2006): 740-745.PMID16460876	Immunofluorescence, Immunohistochemistry; Human
Loughney, K., J. Taylor, and V. A. Florio. "3′, 5′-cyclic nucleotide phosphodiesterase 11A: localization in Human tissues." International journal of impotence research 17.4 (2005): 320-325. PMID15800651	Immunohistochemistry, Western Blot; Human
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425	Immunofluorescence, Western Blot; Mouse
D'Andrea, Michael R., et al. "Expression of PDE11A in normal and malignant Human tissues." Journal of Histochemistry & Cytochemistry 53.7 (2005): 895-903. PMID15995148	Immunohistochemistry, Western Blot; Human