PDE1C Blocking Peptide

Product no.: P-PD1C

$155.00

Description
Publications

General Information
Product	PDE1C Peptide
Description	Antigenic Blocking Peptide Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) N-epitope
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.
Accession #	GenBank: U40371.1
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	Q14123
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
Molecular Function	Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding
Subcellular Location	Cytosol
Expression	Expressed in several tissues, including brain and heart.
Structure	Homodimer
Alternative Nomenclature	5''-cyclic nucleotide phosphodiesterase 1C antibody Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody Cam PDE 1C antibody HCAM3 antibody HSPDE1C1A antibody Human 3'5' cyclic nucleotide Phosphodiesterase antibody PDE 1C antibody Phosphodiesterase 1C antibody Phosphodiesterase 1C calmodulin dependent antibody

Protein information supplied by UniProt

Fabgennix PDE1C Antibody has been used in 16 Publications
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602	Immunhistochemistry; Human
Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654	Immunohistochemistry, Western Blot; Mouse
Guibinga, Ghiabe-Henri, Fiona Murray, and Nikki Barron. “HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?” Ed. Kjetil Tasken. PLoS ONE 8.5 (2013): e63333. PMC3653951	Western Blot; Human
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350. PMID21653225	Immunofluorescence, Western Blot; Mouse
Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011): 152-160.PMID20807569	Western Blot; Human
Abusnina, Abdurazzag, et al. "Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integRator UHRF1." Molecular nutrition & food research 55.11 (2011): 1677-1689. PMID22045655	Western Blot; Human
Dong, Hongli, et al. "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." Biochemical pharmacology 79.3 (2010): 321-329. PMID19737543	Western Blot; Human
Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, IntegRative and CompaRative Physiology 297.5 (2009): R1469–R1476. PMC2777770	Confocal Microscopy, Immunofluorescence, Immunohistochemistry, Western Blot; Mouse
Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009): 605–614. PMC2803251	Western Blot; Rat
Ortiz-Capisano, M. Cecilia, et al. "Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells." American Journal of Physiology-Regulatory, IntegRative and CompaRative Physiology 297.5 (2009): R1469-R1476. PMID19741056	Confocal Microscopy, Immunohistochemistry, Western Blot; Rat
Deplano, Stefania, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase during ontogenesis of chick retina." Journal of neuroscience research 86.5 (2008): 1017-1023. PMID18041092	Immunohistochemistry, Western Blot; Chicken
Dunkern, Torsten R., and Armin Hatzelmann. "Characterization Of Inhibitors Of Phosphodiesterase 1C On A Human Cellular System." FEBS Journal 274.18 (2007): 4812-4824. PMID17697115	Western Blot; Human
Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007): L294-L303. PMID16980375	Western Blot; Human
Santone, Rocco, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase in adult Rat retina." Journal of neuroscience research 84.5 (2006): 1020-1026.PMID16881052	Confoal Microscopy, Immunohistochemistry, Western Blot; Rat
Dolci, Susanna, et al. "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases." Biochemical and biophysical research communications 341.3 (2006): 837-846. PMID16455054	Immunofluorescence, Immunodepletion, Western Blot; Human
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508.PMID15856425	Immunofluorescence, Western Blot; Mouse