PDE2A Blocking Peptide

Product no.: P-PD2A.n

$155.00

Description
Publications

General Information
Product	PDE2A Peptide
Description	Antigenic Blocking Peptide Phosphodiesterase 2A, cGMP-stimulated N-epitope
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	Synthetic peptide corresponding to unique N-terminal amino acid sequence on PDE2A gene.
Accession #	GenBank: EAW74861.1
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	UPI000003B340
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Molecular Function	Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis
Subcellular Location	Multi-pass membrane protein
Expression	bundant in adipose tissues.
Structure	Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6.
Alternative Nomenclature	5''-cyclic phosphodiesterase antibody cGMP dependent 3'5' cyclic phosphodiesterase antibody cGMP stimulated phosphodiesterase 1 antibody cGMP stimulated phosphodiesterase 4 antibody cGMP-dependent 3'' antibody CGS PDE antibody Cyclic GMP stimulated phosphodiesterase antibody PDE 2A antibody PDE 2A1 antibody PDE 2A4 antibody PDE2A antibody Phosphodiesterase 2A cGMP stimulated antibody

Protein information supplied by UniProt

Fabgennix PDE2A Antibody has been used in 34 Publications

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602

Immunohistochemistry; Human

Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994

Immunohistochemistry, Western Blot; Human

Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25550199

Western Blot; Mouse

Rentsendorj, Otgonchimeg, Franco R. D'Alessio, and David B. Pearse. "Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages." Journal of leukocyte biology 96.5 (2014): 907-915. PMID25063878

Western Blot; Mouse

Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014): 1001-1010. PMID24463006

Western Blot; Rat

Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654

Immunohistochemistry, Western Blot; Mouse

Hiramoto, Kenichi, et al. "Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells." Cellular signalling 26.9 (2014): 1807-1817. PMID24705027

Western Blot; Human

MORITA, HIROSHI et al. “Characterization of Phosphodiesterase 2A in Human Malignant Melanoma PMP Cells.” Oncology Reports 29.4 (2013): 1275–1284. PMC3621658

Western Blot; Human

Brechbühl, Julien, Fabian Moine, and Marie-Christine Broillet. “Mouse Grueneberg Ganglion Neurons Share Molecular and Functional Features withC. Elegans Amphid Neurons.” Frontiers in Behavioral Neuroscience 7 (2013): 193. PMC3856774