Phospho-Doublecortin Blocking Peptide

General Information

Product

Phospho-Doublecortin Peptide

Description

Antigenic Blocking Peptide Phosphorylated Neuronal migration protein doublecortin

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 200-250 on human Mesencephalic astrocyte-derived neurotrophic factor.

Accession #

NCBI:  NP_835365

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Modification

Phosphorylated

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

O43602

Overview

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.

Molecular Function

Developmental protein

Subcellular Location

Cytoplasm, Cell projection

Expression

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Structure

Contains 2 doublecortin domains.

Alternative Nomenclature

DBCN antibody
Dbct antibody
DC antibody
DCX antibody
Doublecortex antibody
Doublin antibody
Lis X antibody
Lissencephalin X antibody
Lissencephaly X linked doublecortin antibody
LISX antibody
Neuronal migration protein doublecortin antibody
SCLH antibody
XLIS antibody