Phospho-MERTK Blocking Peptide

Product no.: P-PMKT

$195.00

Description
Publications

General Information
Product	Phospho-MERTK Peptide
Description	Antigenic Blocking Peptide Phosphorylated Tyrosine-protein kinase Mer
Verified Applications	Immunodepletion, Immunocompetition
Peptide Description	Synthetic peptide corresponding to amino acids 746-757 of Human MERTK. Sequence: CKKIY_pSGDY_pY_pRQG
Accession #	NCBI: NP_075232.1
Physical Properties
Quantity	250 µg
Volume	100 µl
Form	Antigenic Blocking Peptide
Storage	-20⁰C for long term storage
Application Protocol
Competition/Depletion assay	Refer to competition assay protocol
Protein
Uniprot #	P57097
Overview	Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules.
Molecular Function	Kinase, Receptor, Transferase, Tyrosine-protein kinase
Subcellular Location	Membrane; Single-pass type I membrane protein
Structure	Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.
Alternative Nomenclature	c MER antibody c mer proto oncogene tyrosine kinase antibody Eyk antibody MER antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody

Protein information supplied by UniProt

FabGennix Phospho-MerTK Antibody has been used in 26 Publications

Applications: Confocal microscopy, Flow cytometry, Immunocytochemistry, Immunohistochemistry Immunofluorescence, and Western blot

Reactivity: Human, Mouse, and Rat

ZCai, Bishuang, et al. "MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity." Sci. Signal. 11.549 (2018).

PMID: 30254055

Applications: Western Blot

Reactivity: Human

Zhang, Bing, et al. "Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3." Molecular immunology 76 (2016).

PMID: 27419619

Applications: Western Blot

Reactivity: Mouse

Das, Amitava, et al. "Correction of MFG-E8 resolves inflammation and promotes cutaneous wound healing in diabetes." The Journal of Immunology 196.12 (2016).

PMID: 27194784

Applications: Western Blot

Reactivity: Mouse

Cai, Bishuang, et al. "MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation." Proceedings of the National Academy of Sciences 113.23 (2016).

PMID: 27199481

Applications: Western Blot

Reactivity: Mouse

Ginisty, Aurélie, et al. "Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K‐Dependent Factor Protein S." STEM CELLS 33.2 (2015).

PMID: 25308179

Applications: Western Blot

Reactivity: Rat

Nguyen, Khanh-Quynh N., et al. "Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity." Journal of Biological Chemistry 289.37 (2014).

PMID: 25074939

Applications: Western Blot

Reactivity: Human

Law, Ah-Lai, et al. "Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis." Journal of Biological Chemistry (2014).

PMID: 25538233

Applications: Western Blot

Reactivity: Mouse

Suleiman, Lutfi, Claude Négrier, and Habib Boukerche. "Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer." Critical Reviews in oncology/hematology 88.3 (2013).

PMID: 23065156

Applications: Western Blot

Reactivity: Mouse

Wang, Y, et al. "Mer Receptor Tyrosine Kinase Promotes Invasion and Survival In Glioblastoma Multiforme." Oncogene 32.7 (2013): 872-882.

PMID: 22469987

Applications: Confocal Microscopy, Immunofluorescence, Immunohistochemistry, Western Blot

Reactivity: Human

Choi, Ji-Yeon, et al. "Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation." Journal of Pharmacology and Experimental Therapeutics 344.2 (2013).

PMID: 23197771

Applications: Western Blot

Reactivity: Mouse

Yefimova, Marina G. et al. “A Chimerical Phagocytosis Model Reveals the Recruitment by Sertoli Cells of Autophagy for the Degradation of Ingested Illegitimate Substrates.” Autophagy 9.5 (2013).

PMCID: 3669177

Applications: Confocal Microscopy, Immunocytochemistry, Immunofluorescence, Western Blot

Reactivity: Human

Click Here for the complete list of all FabGennix Phospho-MerTK Antibody publications

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