Phospho-Src Blocking Peptide

General Information

Product

Phospho-Src Peptide

Description

Antigenic Blocking Peptide Phosphorylated Proto-oncogene tyrosine-protein kinase Src Antibody N-epitope

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

N-epitope phosphorylated synthetic peptide taken within amino acid region 200-300 on human Src protein.  Phosphorylated Tyr-215 residue.

Accession #

NCBI:  NP_005408.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P12931

Overview

Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis migration, and transformation.

Molecular Function

ATP binding, ephrin receptor binding, heme binding, ion channel binding, enzyme binding, growth factor receptor binding, integrin binding, kinase activity

Subcellular Location

Cell membrane, mitochondrion inner membrane, nucleus, cytoplasm (Note: Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and SH3 domain.)

Expression

Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.

Alternative Nomenclature

ASV antibody

Avian sarcoma virus antibody

Neuronal CSRC tyrosine specific protein kinase antibody

p60 Src antibody

SRC1 antibody

Tyrosine kinase pp60c src antibody

v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog antibody