Phospho-trp Blocking Peptide

General Information

Product

Phospho-trp Peptide

Description

Antigenic Blocking Peptide Phosphorylated Transient Receptor Potential isoform A

Verified Applications

Immunocompeition, Immunodepletion

Peptide Description

Synthetic Peptide

Accession #

NCBI:  NP_476768.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P19334

Overview

A light-sensitive calcium channel that is required for inositide-mediated Ca2+ entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca2+ influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling.

Molecular Function

Calcium channel, Ion channel, Calmodulin activity

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development.

Structure

The C-terminus interacts with a PDZ domain of inaD to form the core of the inaD signaling complex. Other members of the complex include norpA (PLC), inaC (PKC), and possibly trpl, ninaC, FKBP59, calmodulin and rhodopsin. Forms homomultimers and heteromult

Alternative Nomenclature

DmTRP antibody

dTRP antibody

Transient receptor potential antibody