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General Information
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Product
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REST / NRSF Peptide
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Description
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Antigenic Blocking Peptide RE1-silencing transcription factor Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 1000-1097 on human REST protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q13127
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Overview
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Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.
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Molecular Function
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Repressor, Chromatin binding, Core promoter binding
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Subcellular Location
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Nucleus
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Expression
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Ubiquitous, expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovaries.
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Structure
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Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL.
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Alternative Nomenclature
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Neural Restrictive Silencer Factor antibody
NRSF antibody
RE1 silencing transcription factor antibody
Repressor binding to the X2 box antibody
REST antibody
X2 box repressor antibody
XBR antibody
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REST / NRSF Antibody
REST / NRSF Antibody FITC
REST / NRSF Antibody BIOTIN
REST / NRSF Positive Control
