General Information |
|
Product |
REST / NRSF Peptide |
Description |
Antigenic Blocking Peptide RE1-silencing transcription factor Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 1000-1097 on human REST protein. |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
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|
|
Uniprot # |
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Overview |
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. |
Molecular Function |
Repressor, Chromatin binding, Core promoter binding |
Subcellular Location |
Nucleus |
Expression |
Ubiquitous, expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovaries. |
Structure |
Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL. |
Alternative Nomenclature |
Neural Restrictive Silencer Factor antibody NRSF antibody RE1 silencing transcription factor antibody Repressor binding to the X2 box antibody REST antibody X2 box repressor antibody XBR antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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REST-101AP | |||
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REST-FITC | |||
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REST-BIOTIN | |||
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PC-REST | |||
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