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General Information
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Product
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ROCK2 Peptide
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Description
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Antigenic Blocking Peptide Rho-associated protein kinase 2 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 1300-1388 on human ROCK2 protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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O75116
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Overview
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Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Cell membrane; Peripheral membrane protein, Nucleus
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Structure
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Homodimer. Interacts with IRS1, RHOB and RHOC. Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1.
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Alternative Nomenclature
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coiled-coil-containing protein kinase 2 antibody
KIAA0619 antibody
p164 ROCK 2 antibody
Rho associated, coiled coil containing protein kinase II antibody
ROK alpha antibody
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ROCK2 Antibody
ROCK2 Antibody FITC
ROCK2 Antibody BIOTIN
ROCK2 Positive Control
