AMPK alpha 2 Positive Control

General Information

Product

AMPK alpha 2 Positive Control

Description

Western Blot Positive Control 5'-AMP-activated protein kinase catalytic subunit alpha-2

Verified Applications

WB

Immunogen

Purified Protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q09137

Overview

Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators.

Molecular Function

[acetyl-CoA carboxylase] kinase activity

[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

AMP-activated protein kinase activity

ATP binding Source: RGD

chromatin binding

histone serine kinase activity

metal ion binding -KW

protein binding

Subcellular Location

Nucleus, Cytoplasm

Expression

Skeletal muscle, lower levels in liver, heart and kidney.

Structure

The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity.

Alternative Nomenclature

5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody

ACACA kinase antibody

Acetyl-CoA carboxylase kinase antibody

AMPK alpha 2 chain antibody

AMPK subunit alpha-2 antibody

AMPK2 antibody

AMPKa2 antibody

HMGCR kinase antibody

Hydroxymethylglutaryl-CoA reductase kinase antibody

PRKAA antibody

PRKAA2 antibody

Protein kinase AMP activated alpha 2 catalytic subunit antibody