Aurora A Positive Control

General Information

Product

Aurora A Positive Control

Description

Western Blot Positive Control Aurora Kinase A

Verified Applications

WB

Accession #

NCBI:  NP_695208

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q3MHU2

Overview

Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes.

Molecular Function

ATP binding

histone serine kinase activity

protein heterodimerization activity

protein kinase activity

protein kinase binding

protein serine/threonine/tyrosine kinase activity

protein serine/threonine kinase activity

ubiquitin protein ligase binding

Subcellular Location

centrosome 

spindle pole 

cilium basal body

centriole

Expression

Detected in embryonic neurons in dorsal root ganglia and brain cortex (at protein level). Highly expressed in testis, in about one third of the seminiferous tubules. Expression is restricted to specific spermatocytes nearing completion of prophase, with levels falling off on transition to elongated spermatids. Highly expressed in the ovary, expression in the oocyte starts around the transition to large growing follicle. Abundant expression is seen in the proliferating granulosa and thecal cells of the growing follicle, and in the young corpus luteum. Very weakly expressed in spleen and intestine.

Structure

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

Alternative Nomenclature

AIK antibody

ARK1 antibody

AURA antibody

Aurora 2 antibody

Aurora A antibody

Aurora kinase A antibody

Aurora-related kinase 1 antibody

Aurora/IPL1 like kinase antibody

AURORA2 antibody

Breast tumor-amplified kinase antibody

BTAK antibody

hARK1 antibody

IAK antibody

IPL1 related kinase antibody

PPP1R47 antibody

Protein phosphatase 1, regulatory subunit 47 antibody

Serine/threonine kinase 15 antibody

Serine/threonine kinase 6 antibody

Serine/threonine-protein kinase aurora-A antibody

STK15 antibody

STK6 antibody

STK7 antibody