General Information |
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Product |
GBA Positive Control |
Description |
Western Blot Positive Control Glucosylceramidase Antibody |
Verified Applications |
WB |
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Quantity |
5 Applications |
Volume |
Inquire |
Concentration | The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Uniprot # |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:9201993, PubMed:24211208). Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698). Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (PubMed:19279011). Also plays a role in cholesterol metabolism (PubMed:24211208, PubMed:26724485). May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208, PubMed:26724485). The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (PubMed:24211208). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (PubMed:26724485). Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (PubMed:24211208, PubMed:26724485). |
Overview |
glucosylceramidase activity glucosyltransferase activity hydrolase activity scavenger receptor binding signaling receptor binding steryl-beta-glucosidase activity |
Molecular Function |
Lysosome |
Subcellular Location |
Interacts with saposin-C (PubMed:10781797). Interacts with SCARB2 (PubMed:18022370). Interacts with TCP1 (PubMed:21098288). May interact with SNCA; may inhibit the glucosylceramidase activity (PubMed:23266198). Interacts with GRN; this interaction prevents aggregation of GBA-SCARB2 complex via interaction with HSPA1A upon stress (PubMed:27789271). |
Expression |
Belongs to the glycosyl hydrolase 30 family. |
Structure |
Lysosomal acid glucosylceramidase |
Alternative Nomenclature |
Lysosomal acid glucosylceramidase |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
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GLCM-101AP | |||
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P-GLCM | |||
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GLCM-FITC | |||
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GLCM-BIOTIN | |||
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