SREBP2 Positive Control

General Information

Product

SREBP2 Antibody Western Blot Positive Control

Description

Western Blot Positive Control Sterol regulatory element binding protein-2 Antibody

Verified Applications

WB

Immunogen

Purified Protein

Accession #

GenBank: AAA50746.1

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q12772

Overview

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.

Molecular Function

Activator, E-box binding, protein C-terminus binding

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein, Golgi apparatus membrane; Multi-pass membrane protein, Cytoplasmic vesicle > COPII-coated vesicle membrane; Multi-pass membrane protein

Expression

Ubiquitously expressed in adult and fetal tissues.

Structure

Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF13

Alternative Nomenclature

AI608257 antibody

bHLHd2 antibody

Class D basic helix-loop-helix protein 2 antibody

Processed sterol regulatory element-binding protein 2 antibody

SREBF 2 antibody

SREBP2 antibody

Sterol regulatory element-binding transcription factor 2 antibody