TLR7 Positive Control

General Information

Product

TLR7 Antibody Western Blot Positive Control

Description

Western Blot Positive Control Toll-like receptor 7 precursor Antibody

Verified Applications

WB

Immunogen

Purified Protein

Accession #

NCBI:  NP_057646.1

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q9NYK1

Overview

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Molecular Function

Receptor, double-stranded RNA bindng, single-stranded RNA binding

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type 1 membrane protein, Endosome, Lysosome, Cytoplasmic vesicle

Expression

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Structure

Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity).

Alternative Nomenclature

PRO285 antibody

TLR 7 antibody

Toll like receptor 7 antibody

UNQ248 antibody