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General Information
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Product
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TLR7 Antibody FITC-Conjugated
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Description
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FITC-Conjugated Toll-like receptor 7 precursor Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Cat, Human, Mouse, Pig
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Immunogen
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Synthetic peptide taken within amino acid region 175-225 on human TLR7 protein.
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Accession #
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NCBI: NP_057646.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.65-0.72 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000
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ELISA
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1:20,000
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9NYK1
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Overview
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Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
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Molecular Function
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Receptor, double-stranded RNA bindng, single-stranded RNA binding
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Subcellular Location
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Endoplasmic reticulum membrane; Single-pass type 1 membrane protein, Endosome, Lysosome, Cytoplasmic vesicle
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Expression
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Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
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Structure
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Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity).
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Alternative Nomenclature
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PRO285 antibody
TLR 7 antibody
Toll like receptor 7 antibody
UNQ248 antibody
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TLR7 Antibody
TLR7 Blocking Peptide
TLR7 Antibody BIOTIN
TLR7 Positive Control
