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General Information
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Product
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TLR9 Positive Control
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Description
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Western Blot Positive Control Toll-like receptor 9
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Verified Applications
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WB
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Immunogen
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Purified Protein
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Accession #
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GenBank: AAQ89443.1
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9NR96
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Overview
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Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides.
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Molecular Function
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Receptor, Interleukin-1 receptor binding, siRNA binding
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Subcellular Location
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Endoplasmic reticulum membrane; Single-pass type 1 membrane protein, Endosome, Lysosome, Cytoplasmic vesicle
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Expression
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Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
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Structure
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Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity
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Alternative Nomenclature
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CD 289 antibody
TLR 9 antibody
Toll like receptor 9 isoform A precursor antibody
Toll like receptor 9 isoform B antibody
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TLR9 Antibody
TLR9 Antibody FITC
TLR9 Blocking Peptide
TLR9 Antibody BIOTIN
