UFD1L Positive Control

General Information

Product

UFD1L Antibody Western Blot Positive Control

Description

Western Blot Positive Control UFD1L Purified 20 kDa UFD1L protein Antibody

Verified Applications

WB

Immunogen

Purified Protein

Accession #

GenBank: CAG30493.1

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q92890

Overview

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins  from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.

Molecular Function

Ubiquitin-specific protease activity

Subcellular Location

Nucleus; Cytosol

Expression

Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

Structure

Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13.

Alternative Nomenclature

UB fusion protein 1 antibody

Ubiquitin fusion degradation 1 like (yeast) antibody

Ubiquitin fusion degradation protein 1 homolog antibody

UFD1 antibody

UFD1L antibody